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Lithium

Original Wikipedia articleNot linked yet. It gets linked once the exact article is confirmed.

Dosage

Awaiting sourceDose ranges from PsychonautWiki or TripSit.
What dose are you on? (self-reported, unverified)
Read this first. These numbers come from anonymous visitors typing in a box. Nobody checks them. People misjudge, mistype, troll, or take untested products of unknown strength. They are not a dose guide and never override the sourced table above. They exist only so the sourced ranges can be compared with what people say they take. If you are deciding what to take, use the sourced table, start low, and read the risks section.
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Duration

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Mixing

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

TripSit combination chart

TripSit rates each pairing. Only pairings with a number carry a citation from TripSit. See the whole chart, with TripSit's note for every pairing.

Dangerous

2c-t-x[1–5] TS2c-x[1–5] TSdmt[1–5] TSdox[1–5] TSlsd[1–6] TSmdma[7–10] TSmescaline[1–5] TSmushrooms[1–5] TSnbomes[1–5][11] TStramadol[9][12–17] TS

Low Risk & No Synergy

nitrous[18] TSssris[19–22] TS

Low Risk & Decrease

cocaine[23][24] TS

Risks and toxicity

Awaiting sourceToxicity, overdose signs and dependence risk from harm reduction sites and journals.

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

Awaiting sourceSubjective and physical effects from PsychonautWiki or TripSit.

Overview

Awaiting sourceA summary from a harm reduction site or Wikipedia.

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Pharmacology

Awaiting sourcePharmacology from Wikipedia and the journal papers it cites.

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

User reports

Erowid erowid.org

Listings
Awaiting sourceExperience Vault listing and report categories.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Bluelight bluelight.org

Listings
Awaiting sourceTrip report threads and this substance's discussion forum.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Reddit reddit.com

Listings
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Top stories
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Pop culture

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References

  1. Journal / agency Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths. Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports
  2. Harm reduction site Erowid. Erowid Interactions
  3. Harm reduction site freshboi88. I Was Only on One Dose
  4. Harm reduction site YouWerentYouAnymore. Brought My Worst Thoughts to Life
  5. Journal / agency Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg. Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics
  6. Journal / agency Edwards, C., Van Gerpen, S., & Anand, V. New-Onset Seizures in an Adolescent Following Use of LSD while on Low-Dose Lithium Therapy: A Case Study. (2024)
  7. Journal / agency Lokesh Shahani. Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome
  8. Other Charles DeBattista, Mehmet Sofuoglu, and Alan F. Schatzberg. Serotonergic Synergism: The Risks and Benefits of Combining the Selective Serotonin Reuptake Inhibitors with Other Serotonergic Drugs
  9. Journal / agency Olivier Massot Ph.D, Jean-Claude Rousselle Ph.D, Marie-Paule Fillion MSc, Dominique Januel MD, Mathieu Plantefol MSc & Gilles Fillion Ph.D. 5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders
  10. Journal / agency Philip J. Cowen. New drugs, old problems: Revisiting… Pharmacological management of treatment-resistant depression
  11. Journal / agency Umemura, Y., Andrew, T. A., Jacobs, V. L., Giustini, A. J., Lewis, L. D., & Filiano, J. J. Fatal 251-NBOMe Intoxication: A New Recreational Risk. (2015)
  12. Journal / agency Steven C. Julius, Richard P. Brenner. Myoclonic seizures with lithium
  13. Journal / agency Charles DeBattista, Mehmet Sofuoglu, and Alan F. Schatzberg. Serotonergic Synergism: The Risks and Benefits of Combining the Selective Serotonin Reuptake Inhibitors with Other Serotonergic Drugs
  14. Journal / agency Sameer Hassamal, Karen Miotto, William Dale, Itai Danovitch . Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures
  15. Journal / agency Boostani R, Derakhshan S. Tramadol induced seizure: A 3-year study
  16. Journal / agency Lagard, C.; Vodovar, D.; Chevillard, L.; Callebert, J.; Caillé, F.; Pottier, G.; Liang, H.; Risède, P.; Tournier, N.; Mégarbane, B. Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat
  17. Journal / agency Sansone RA, Sansone LA. Tramadol
  18. Other Drugbank. Lithium Carbonate
  19. Journal / agency Finley, P. R. Drug Interactions with Lithium: An Update. (2016)
  20. Journal / agency Hawley CJ, Loughlin PJ, Quick SJ, Gale TM, Sivakumaran T, Hayes J, McPhee S. Efficacy, safety and tolerability of combined administration of lithium and selective serotonin reuptake inhibitors: a review of the current evidence. (2000)
  21. Journal / agency Müller-Oerlinghausen, B. Drug Interactions with Lithium. (1999)
  22. Journal / agency Bauer, Michael PhD, MD; Linden, Michael MD; Schaaf, Berthold; Weber, Hans J. MD. Adverse Events and Tolerability of the Combination of Fluoxetine/Lithium Compared With Fluoxetine. (1996)
  23. Journal / agency Flemenbaum, A. Antagonism of behavioral effects of cocaine by lithium. (1977)
  24. Journal / agency Cronson, A. J., & Flemenbaum, A. Antagonism of Cocaine Highs by Lithium. (1981)

Text and values on this page are quoted from TripSit factsheets. Each value links to the exact revision it came from.