Cannabis

Effects

SedationAppetite enhancementMuscle relaxationMuscle spasmsNauseaPain reliefVasodilationCreativity EnhancementAnxiety suppressionAnxietyDream suppressionEmotion enhancementMindfulnessParanoiaSleepiness TS

Overview

Cannabis (also known as THC, marijuana, weed, pot, grass, hemp, zaza, kush, and many others) is a preparation of the cannabis plant that produces psychoactive effects when consumed (via smoking, vaporizing, or ingestion). It is the most used illicit substance in the world. The mechanism of action is binding activity at cannabinoid receptors distributed throughout the body.[1–10] PW⚠ PsychonautWiki itself has flagged this text: citation needed.

A common and widely used psychoactive plant, which is beginning to enjoy legal status for medical and even recreational use in some parts of the world. Usually smoked or eaten, primary effects are relaxation and an affinity towards food - a state described as being 'stoned.'[11–31] TS

Cannabis (/ˈkænəbᵻs/), commonly known as marijuana (/ˌmærəˈwɑːnə/), weed, pot, Mary Jane, and ganja, among other names, is a non-chemically uniform psychoactive drug from the Cannabis plant. Native to Central or South Asia, cannabis has been used as a drug for both recreational and entheogenic purposes and in various traditional medicines for centuries. Tetrahydrocannabinol (THC) is the main psychoactive component of cannabis, which is one of the 483 known compounds in the plant, including at least 65 other cannabinoids, such as cannabidiol (CBD). Cannabis can be used by smoking, vaporizing, within food, or as an extract.[32][33] WP

Cannabis has various mental and physical effects, which include euphoria, altered states of mind and sense of time, difficulty concentrating, impaired short-term memory, impaired body movement (balance and fine psychomotor control), relaxation, and an increase in appetite. Onset of effects is felt within minutes when smoked, but may take up to 90 minutes when eaten (as orally consumed drugs must be digested and absorbed). The effects last for two to six hours, depending on the amount used. At high doses, mental effects can include anxiety, delusions (including ideas of reference), hallucinations, panic, paranoia, and cannabis-induced psychotic disorder (CIPD). There is a strong relation between cannabis use and the risk of psychosis, with cannabis use considered a contributory cause of psychosis. Physical effects include increased heart rate, difficulty breathing, nausea, and behavioral problems in children whose mothers used cannabis during pregnancy; short-term side effects may also include dry mouth and red eyes. Long-term adverse effects may include addiction, decreased mental ability in those who started regular use as adolescents, heart disease, chronic coughing, susceptibility to respiratory infections, and cannabinoid hyperemesis syndrome.[34][35][36] WP

Cannabis is mostly used recreationally or as a medicinal drug, although it may also be used for spiritual purposes. Evidence supports only a few approved uses of cannabinoids and most medical claims, such as efficacy for insomnia or acute pain, lack sufficient evidence. In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65). It is the most commonly used largely-illegal drug in the world, with the highest use among adults in Zambia, the United States, Canada, and Nigeria. Since the 1970s, the potency of illicit cannabis has increased, with THC levels rising and CBD levels dropping.[37] WP

Cannabis plants have been grown since at least the 3rd millennium BCE and there is evidence of it being smoked for its psychoactive effects around 500 BCE in the Pamir Mountains, Central Asia. Since the 14th century, cannabis has been subject to legal restrictions. The possession, use, and cultivation of cannabis has been illegal in most countries since the 20th century. Uruguay became the first country to legalize recreational use of cannabis in 2013. Other countries to do so are Canada, Georgia, Germany, Luxembourg, Malta, South Africa, and Thailand. In the U.S., the recreational use of cannabis is legalized in 24 states, 3 territories, and the District of Columbia, though the drug remains federally illegal. In Australia, it is legalized only in the Australian Capital Territory. WP

History

Ancient history

Cannabis is indigenous to Central or South Asia and its uses for fabric and rope dates back to the Neolithic age in China and Japan. It is unclear when cannabis first became known for its psychoactive properties. The oldest archeological evidence for the burning of cannabis was found in Romanian kurgans dated 3,500 BC, and scholars suggest that the drug was first used in ritual ceremonies by Proto-Indo-European tribes living in the Pontic-Caspian steppe during the Chalcolithic period, a custom they eventually spread throughout Western Eurasia during the Indo-European migrations. Some research suggests that the ancient Indo-Iranian drug soma, mentioned in the Vedas, sometimes contained cannabis. This is based on the discovery of a basin containing cannabis in a shrine of the second millennium BC in Turkmenistan.[69–74] WP

Cannabis was known to the ancient Assyrians, who discovered its psychoactive properties through the Iranians. Using it in some religious ceremonies, they called it qunubu (meaning "way to produce smoke"), a probable origin of the modern word cannabis. The Iranians also introduced cannabis to the Scythians, Thracians and Dacians, whose shamans (the kapnobatai – "those who walk on smoke/clouds") burned cannabis infructescence to induce trance. The plant was used in China before 2800 BC, and found therapeutic use in India by 1000 BC, where it was used in food and drink, including bhang.[75–79] WP

Cannabis has an ancient history of ritual use and has been used by religions around the world. It has been used as a drug for both recreational and entheogenic purposes and in various traditional medicines for centuries. The earliest evidence of cannabis smoking has been found in the 2,500-year-old tombs of Jirzankal Cemetery in the Pamir Mountains in Western China, where cannabis residue were found in burners with charred pebbles possibly used during funeral rituals. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus. It was used by Muslims in various Sufi orders as early as the Mamluk period, for example by the Qalandars. Smoking pipes uncovered in Ethiopia and carbon-dated to around c. AD 1320 were found to have traces of cannabis.[80–87] WP

Modern history

Cannabis was introduced to the New World by the Spaniards in 1530–1545. Following an 1836–1840 travel in North Africa and the Middle East, French physician Jacques-Joseph Moreau wrote on the psychological effects of cannabis use; he founded the Paris' Club des Hashischins in 1844. In 1842, Irish physician William Brooke O'Shaughnessy, who had studied the drug while working as a medical officer in Bengal with the East India Company, brought a quantity of cannabis with him on his return to Britain, provoking renewed interest in the West. Examples of classic literature of the period featuring cannabis include Les paradis artificiels (1860) by Charles Baudelaire and The Hasheesh Eater (1857) by Fitz Hugh Ludlow.[88–92] WP

Cannabis was criminalized in some countries beginning in the 14th century and was illegal in most countries by the middle of the 20th century. The colonial government of Mauritius banned cannabis in 1840 over concerns on its effect on Indian indentured workers; the same occurred in Singapore in 1870. In the United States, the first restrictions on sale of cannabis came in 1906 (in the District of Columbia). Canada criminalized cannabis in The Opium and Narcotic Drug Act, 1923, before any reports of the use of the drug in Canada, but eventually legalized its consumption for recreational and medicinal purposes in 2018.[93–97] WP

In 1925, a compromise was made at an international conference in Geneva about the Second International Opium Convention that banned exportation of "Indian hemp" to countries that had prohibited its use, and requiring importing countries to issue certificates approving the importation and stating that the shipment was required "exclusively for medical or scientific purposes". It also required parties to "exercise an effective control of such a nature as to prevent the illicit international traffic in Indian hemp and especially in the resin". In the United States in 1937, the Marihuana Tax Act was passed, and prohibited the production of hemp in addition to cannabis.[98][99][100] WP

In 1972, the Dutch government divided drugs into more- and less-dangerous categories, with cannabis being in the lesser category. Accordingly, possession of 30 g or less was made a misdemeanor. Cannabis has been available for recreational use in coffee shops since 1976. Cannabis products are only sold openly in certain local "coffeeshops" and possession of up to 5 g for personal use is decriminalized, however: the police may still confiscate it, which often happens in car checks near the border. Other types of sales and transportation are not permitted, although the general approach toward cannabis was lenient even before official decriminalization.[101–105] WP⚠ The source also gives this in other units.

In Uruguay, President Jose Mujica signed legislation to legalize recreational cannabis in December 2013, making Uruguay the first country in the modern era to legalize cannabis. In August 2014, Uruguay legalized growing up to six plants at home, as well as the formation of growing clubs (Cannabis social club), and a state-controlled marijuana dispensary regime. WP

As of 17 October 2018, when recreational use of cannabis was legalized in Canada, dietary supplements for human use and veterinary health products containing not more than 10 parts per million of THC extract were approved for marketing; Nabiximols (as Sativex) is used as a prescription drug in Canada.[97] WP

The United Nations' World Drug Report stated that cannabis "was the world's most widely produced, trafficked, and consumed drug in the world in 2010", and estimated between 128 million and 238 million users globally in 2015.[106][107] WP

Legal status

• For table of countries, see Wikipedia's global cannabis legalization table. PW
• The legality of cannabis for medical and recreational use varies by country, in terms of its possession, distribution, and cultivation, and (in regards to medical) how it can be consumed and what medical conditions it can be used for. These policies in most countries are regulated by the United Nations Single Convention on Narcotic Drugs that was ratified in 1961, along with the 1971 Convention on Psychotropic Substances and the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.[108][109] PW
• The World Health Organization (WHO) is calling for whole-plant marijuana, as well as cannabis resin, to be removed from Schedule IV—the most restrictive category of a 1961 drug convention signed by countries from around the world.[110] PW

Legality

Since the beginning of the 20th century, most countries have enacted laws against the cultivation, possession or transfer of cannabis. These laws have had an adverse effect on cannabis cultivation for non-recreational purposes, but there are many regions where handling of cannabis is legal or licensed. Many jurisdictions have lessened the penalties for possession of small quantities of cannabis so that it is punished by confiscation and sometimes a fine, rather than imprisonment, focusing more on those who traffic the drug on the black market.[111] WP

In some areas where cannabis use had been historically tolerated, new restrictions were instituted, such as the closing of cannabis coffee shops near the borders of the Netherlands, and closing of coffee shops near secondary schools in the Netherlands. In Copenhagen, Denmark, in 2014, Mayor Frank Jensen discussed possibilities for the city to legalize cannabis production and commerce.[112][113][114] WP

Some jurisdictions use free voluntary or mandatory treatment programs for frequent known users. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution. Political parties, non-profit organizations, and causes based on the legalization of medical cannabis or legalizing the plant entirely (with some restrictions) have emerged in such countries as China and Thailand.[115][116] WP

In December 2012, the U.S. state of Washington became the first state to officially legalize cannabis in a state law (Washington Initiative 502) (but still illegal by federal law), with the state of Colorado following close behind (Colorado Amendment 64). On 1 January 2013, the first cannabis "club" for private marijuana smoking (no buying or selling, however) was allowed for the first time in Colorado. The California Supreme Court decided in May 2013 that local governments can ban medical cannabis dispensaries despite a state law in California that permits the use of cannabis for medical purposes. At least 180 cities across California have enacted bans in recent years. On 30 April 2024, the United States Department of Justice announced it would move to reclassify cannabis from a Schedule I controlled substance to the somewhat less restricted Schedule III. On 18 December 2025, Donald Trump signed an executive order to reclassify cannabis as a Schedule III drug.[117–123] WP

In December 2013, Uruguay became the first country to legalize growing, sale and use of cannabis. After a long delay in implementing the retail component of the law, in 2017 sixteen pharmacies were authorized to sell cannabis commercially. On 19 June 2018, the Canadian Senate passed a bill and Prime Minister Justin Trudeau announced the effective legalization date as 17 October 2018. Canada is the second country to legalize the drug.[97][124–127] WP

In November 2015, Uttarakhand became the first state of India to legalize the cultivation of hemp for industrial purposes. Usage within the Hindu and Buddhist cultures of the Indian subcontinent is common, with many street vendors in India openly selling products infused with cannabis, and traditional medical practitioners in Sri Lanka selling products infused with cannabis for recreational purposes and well as for religious celebrations. Indian laws criminalizing cannabis date back to the colonial period. India and Sri Lanka have allowed cannabis to be taken in the context of traditional culture for recreational/celebratory purposes and also for medicinal purposes.[128][129] WP

On 17 October 2015, Australian health minister Sussan Ley presented a new law that will allow the cultivation of cannabis for scientific research and medical trials on patients.[130] WP

On 17 October 2018, Canada legalized cannabis for recreational adult use making it the second country in the world to do so after Uruguay and the first G7 nation. This legalization comes with regulation similar to that of alcohol in Canada, age restrictions, limiting home production, distribution, consumption areas and sale times. Laws around use vary from province to province including age limits, retail structure, and growing at home. The Canadian Licensed Producer system aims to become the Gold Standard in the world for safe and secure cannabis production, including provisions for a robust craft cannabis industry where many expect opportunities for experimenting with different strains.[127][131–134] WP

As the drug has increasingly been seen as a health issue instead of criminal behavior, cannabis has also been legalized or decriminalized in: Czech Republic, Colombia, Ecuador, Portugal, South Africa and Canada. Medical marijuana was legalized in Mexico in mid-2017 and legalized for recreational use in June 2021.[97][135–145] WP

Germany legalized cannabis for recreational use in April 2024.[146] WP

Legal status by country

As of 2022, Uruguay and Canada are the only countries that have fully legalized the cultivation, consumption and bartering of recreational cannabis nationwide. In the United States, 24 states, 3 territories, and the District of Columbia have legalized the recreational use of cannabis – though the drug remains illegal at the federal level. Laws vary from state to state when it comes to the commercial sale. Court rulings in Georgia and South Africa have led to the legalization of cannabis consumption, but not legal sales. A policy of limited enforcement has also been adopted in many countries, in particular Spain and the Netherlands where the sale of cannabis is tolerated at licensed establishments. Contrary to popular belief, cannabis is not legal in the Netherlands, but it has been decriminalized since the 1970s. In 2021, Malta was the first European Union member to legalize the use of cannabis for recreational purposes. In Estonia, it is only legal to sell cannabis products with a THC content of less than 0.2%, although products may contain more cannabidiol. Lebanon has recently become the first Arab country to legalize the plantation of cannabis for medical use.[127][147–154] WP

Penalties for illegal recreational use ranges from confiscation or small fines to jail time and even death. In some countries, citizens can be punished if they have used the drug in another country, including Singapore and South Korea.[155][156][157] WP

Pharmacology

Mechanism of action

THC is a weak partial agonist at CB₁ receptors, while CBD is a CB₁ receptor antagonist. The CB₁ receptor is found primarily in the brain as well as in some peripheral tissues, and the CB₂ receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells. THC appears to alter mood and cognition through its agonist actions on the CB₁ receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner.[158][159][160] WP

Via CB₁ receptor activation, THC indirectly increases dopamine release and produces psychotropic effects. CBD also acts as an allosteric modulator of the μ- and δ-opioid receptors. THC also potentiates the effects of the glycine receptors. It is unknown if or how these actions contribute to the effects of cannabis.[161–164] WP

Pharmacokinetics

The high lipid-solubility of cannabinoids results in their persisting in the body for long periods of time. Even after a single administration of THC, detectable levels of THC can be found in the body for weeks or longer (depending on the amount administered and the sensitivity of the assessment method). Investigators have suggested that this is an important factor in marijuana's effects, perhaps because cannabinoids may accumulate in the body, particularly in the lipid membranes of neurons.[165][166] WP

Detection in body fluids

THC and its major (inactive) metabolite, THC-COOH, can be measured in blood, urine, hair, oral fluid or sweat using chromatographic techniques as part of a drug use testing program or a forensic investigation of a traffic or other criminal offense. The concentrations obtained from such analyses can often be helpful in distinguishing active use from passive exposure, elapsed time since use, and extent or duration of use. These tests cannot, however, distinguish authorized cannabis smoking for medical purposes from unauthorized recreational smoking. Commercial cannabinoid immunoassays, often employed as the initial screening method when testing physiological specimens for marijuana presence, have different degrees of cross-reactivity with THC and its metabolites. Urine contains predominantly THC-COOH, while hair, oral fluid and sweat contain primarily THC. Blood may contain both substances, with the relative amounts dependent on the recency and extent of usage.[167][168][169] WP

The Duquenois–Levine test is commonly used as a screening test in the field, but it cannot definitively confirm the presence of cannabis, as a large range of substances have been shown to give false positives. Researchers at John Jay College of Criminal Justice reported that dietary zinc supplements can mask the presence of THC and other drugs in urine. However, a 2013 study conducted by researchers at the University of Utah School of Medicine refute the possibility of self-administered zinc producing false-negative urine drug tests.[170][171][172] WP

Chemistry

Pop culture

No references added yet.

References

1. Wikipedia Definition of THC
2. Wikipedia Definition of Marijuana
3. Other Definition of Weed
4. Other Definition of POT
5. Other Definition of Grass
6. Other Definition of HEMP
7. Other Definition of Zaza
8. Other Definition of Kush
9. Harm reduction site Erowid Cannabis Vault : Legal Status
10. Harm reduction site WDR-2010
11. Journal / agency Cannabis use and risk of lung cancer: a case-control study
12. Journal / agency Cannabis smoking and risk of lung cancer in men: a pooled analysis of three studies in Maghreb
13. Journal / agency Cannabis induces a clinical response in patients with Crohn's disease: a prospective placebo-controlled study
14. Journal / agency Effects of cannabis on the adolescent brain
15. Journal / agency Is cannabis neurotoxic for the healthy brain? A meta-analytical review of structural brain alterations in non-psychotic users
16. Journal / agency A controlled family study of cannabis users with and without psychosis
17. Journal / agency How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to
18. Journal / agency The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
19. Journal / agency Marijuana and lung diseases
20. Journal / agency Neuroprotective antioxidants from marijuana
21. Journal / agency Decreased depression in marijuana users
22. Journal / agency Self-reported anal sex practice and sexual risk-taking after marijuana use among a sample of Georgia inmates
23. Journal / agency Effects of marijuana extract and tetrahydrocannabinol on electroencephalographic sleep patterns
24. Journal / agency Association of marijuana use and the incidence of testicular germ cell tumors
25. Journal / agency The effects of combinations of intranasal cocaine, smoked marijuana, and task performance on heart rate and blood pressure
26. Journal / agency Ischemic stroke after use of the synthetic marijuana "spice"
27. Journal / agency Marijuana's effects on human cognitive functions, psychomotor functions, and personality
28. Journal / agency Effects of marijuana on human reaction time and motor control
29. Journal / agency Effects of marijuana on testosterone in male subjects
30. Journal / agency Detection times of marijuana metabolites in urine by immunoassay and GC-MS
31. Other Medical/therapeutic value of cannabis literature review
32. Other cannabis noun – Definition, pictures, pronunciation and usage notes | Oxford Advanced Learner's Dictionary at OxfordLearnersDictionaries.com
33. Other marijuana noun – Definition, pictures, pronunciation and usage notes | Oxford Advanced Learner's Dictionary at OxfordLearnersDictionaries.com
34. Journal / agency Hall, Wayne; Yimer, Tesfa M.; Thorne, Rachel Lees; Hoch, Eva; Burke, Chloe; Gridley, Ad; Hurd, Yasmin L.; Wilson, Jack; Leung, Janni; Freeman, Tom P. Relationships between cannabis use and mental disorders: assessing the coherence of evidence from studies with different methodologies. The Lancet Psychiatry. 2026-07-01. doi:10.1016/S2215-0366(26)00086-6 · PMID 42309106
35. Journal / agency Shrivastava, Amresh; Johnston, Megan; Tsuang, Ming. Cannabis use and cognitive dysfunction. Indian Journal of Psychiatry. 2011. doi:10.4103/0019-5545.86796 · PMID 22135433 · PMC3221171
36. Other Gregory, Andrew. Cannabis use could double risk of heart deaths, study suggests. 17 June 2025
37. Journal / agency Hsu, Michael; Shah, Arya; Jordan, Ayana; Gold, Mark S.; Hill, Kevin P. Therapeutic Use of Cannabis and Cannabinoids. JAMA. 2026-01-27. doi:10.1001/jama.2025.19433 · PMID 41296368
38. Journal / agency Sorensen, Cecilia J.; DeSanto, Kristen; Borgelt, Laura; Phillips, Kristina T.; Monte, Andrew A. Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment—a Systematic Review. Journal of Medical Toxicology. 20 December 2016. doi:10.1007/s13181-016-0595-z · PMID 28000146 · PMC5330965
39. Journal / agency DeVuono, Marieka; Parker, Linda. Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms. Cannabis and Cannabinoid Research. 2020. doi:10.1089/can.2019.0059
40. Journal / agency El Omri, N; Eljaoudi, R; Mekouar, F; Jira, M; Sekkach, Y; Amezyane, T; Ghafir, D. Cannabis arteritis. The Pan African medical journal. 2017. doi:10.11604/pamj.2017.26.53.11694 · PMID 28451030
41. Other Hurd, Yasmin L., et al. “Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects.” Journal of Neuroscience, Society for Neuroscience, 16 Oct. 2019
42. Journal / agency https://www.nih.gov/news-events/news-releases/canSuicidality
43. Journal / agency Price, C., Hemmingsson, T., Lewis, G., Zammit, S., Allebeck, P. Cannabis and suicide: longitudinal study. The British Journal of Psychiatry. December 2009. doi:10.1192/bjp.bp.109.065227
44. Journal / agency Borges, G., Bagge, C. L., Orozco, R. A literature review and meta-analyses of cannabis use and suicidality. Journal of Affective Disorders. 1 May 2016. doi:10.1016/j.jad.2016.02.007
45. Journal / agency Arseneault, L., Cannon, M., Witton, J., Murray, R. M. Causal association between cannabis and psychosis: examination of the evidence. The British Journal of Psychiatry. February 2004. doi:10.1192/bjp.184.2.110
46. Journal / agency Every-Palmer, S. Synthetic cannabinoid JWH-018 and psychosis: An explorative study. Drug and Alcohol Dependence. September 2011. doi:10.1016/j.drugalcdep.2011.01.012
47. Journal / agency Schneir, A. B., Cullen, J., Ly, B. T. “Spice” Girls: Synthetic Cannabinoid Intoxication. The Journal of Emergency Medicine. 1 March 2011. doi:10.1016/j.jemermed.2010.10.014
48. Journal / agency Vearrier, D., Osterhoudt, K. C. A Teenager With Agitation: Higher Than She Should Have Climbed. Pediatric Emergency Care. June 2010. doi:10.1097/PEC.0b013e3181e4f416
49. Journal / agency Hyman SM, Sinha R. Stress-related factors in cannabis use and misuse: implications for prevention and treatment. Journal of Substance Abuse Treatment. June 2009. doi:10.1016/j.jsat.2008.08.005 · PMID 19004601 · PMC2696937
50. Journal / agency Bonn-Miller MO, Vujanovic AA, Feldner MT, Bernstein A, Zvolensky MJ. Posttraumatic stress symptom severity predicts marijuana use coping motives among traumatic event-exposed marijuana users. Journal of Traumatic Stress. August 2007. doi:10.1002/jts.20243 · PMID 17721963
51. Journal / agency Kevorkian S, Bonn-Miller MO, Belendiuk K, Carney DM, Roberson-Nay R, Berenz EC. Associations among trauma, posttraumatic stress disorder, cannabis use, and cannabis use disorder in a nationally representative epidemiologic sample. Psychology of Addictive Behaviors. September 2015. doi:10.1037/adb0000110 · PMID 26415060 · PMC4699174
52. Journal / agency Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, Farrell M, Degenhardt L. Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis. The Lancet. Psychiatry. December 2019. doi:10.1016/s2215-0366(19)30401-8 · PMID 31672337 · PMC6949116
53. Journal / agency Dagan Y, Yager J. Cannabis and Complex Posttraumatic Stress Disorder: A Narrative Review With Considerations of Benefits and Harms. The Journal of Nervous and Mental Disease. August 2020. doi:10.1097/nmd.0000000000001172 · PMID 32433200
54. Journal / agency Calabria, B., Degenhardt, L., Hall, W., Lynskey, M. Does cannabis use increase the risk of death? Systematic review of epidemiological evidence on adverse effects of cannabis use: Adverse effects of cannabis use. Drug and Alcohol Review. 19 January 2010. doi:10.1111/j.1465-3362.2009.00149.x
55. Journal / agency Ashton, C. H. Pharmacology and effects of cannabis: A brief review. The British Journal of Psychiatry. February 2001. doi:10.1192/bjp.178.2.101
56. Journal / agency Hall, W., Solowij, N. Adverse effects of cannabis. The Lancet. 14 November 1998. doi:10.1016/S0140-6736(98)05021-1
57. Harm reduction site https://www.drugbank.ca/drugs/DB00470
58. Journal / agency Kochanowski, M., Kała, M. Tetrahydrocannabinols in clinical and forensic toxicology. Przeglad Lekarski. 2005
59. Journal / agency Galli, J. A., Sawaya, R. A., Friedenberg, F. K. Cannabinoid Hyperemesis Syndrome. Current drug abuse reviews. December 2011
60. Journal / agency Nourbakhsh, M., Miller, A., Gofton, J., Jones, G., Adeagbo, B. Cannabinoid Hyperemesis Syndrome: Reports of Fatal Cases. Journal of Forensic Sciences. January 2019. doi:10.1111/1556-4029.13819
61. Journal / agency Lopez-Quintero, C., Cobos, J. P. de los, Hasin, D. S., Okuda, M., Wang, S., Grant, B. F., Blanco, C. Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Drug and alcohol dependence. 1 May 2011. doi:10.1016/j.drugalcdep.2010.11.004
62. Journal / agency Borgelt, L. M., Franson, K. L., Nussbaum, A. M., Wang, G. S. The Pharmacologic and Clinical Effects of Medical Cannabis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. February 2013. doi:10.1002/phar.1187
63. Journal / agency Sewell, R. A., Poling, J., Sofuoglu, M. The Effect of Cannabis Compared with Alcohol on Driving. American Journal on Addictions. January 2009. doi:10.1080/10550490902786934
64. Journal / agency Gordon, A. J., Conley, J. W., Gordon, J. M. Medical Consequences of Marijuana Use: A Review of Current Literature. Current Psychiatry Reports. 14 November 2013. doi:10.1007/s11920-013-0419-7
65. Journal / agency Lichtman, A. H., Martin, B. R. Cannabinoid tolerance and dependence. Handbook of Experimental Pharmacology. 2005. doi:10.1007/3-540-26573-2_24
66. Journal / agency Watson, S. J. Marijuana and Medicine: Assessing the Science Base: A Summary of the 1999 Institute of Medicine Report. Archives of General Psychiatry. 1 June 2000. doi:10.1001/archpsyc.57.6.547
67. Journal / agency Ellis, G. M., Mann, M. A., Judson, B. A., Schramm, N. T., Tashchian, A. Excretion patterns of cannabinoid metabolites after last use in a group of chronic users. Clinical Pharmacology and Therapeutics. November 1985. doi:10.1038/clpt.1985.226
68. Journal / agency Winstock, A. R., Ford, C., Witton, J. Assessment and management of cannabis use disorders in primary care. BMJ. 1 April 2010. doi:10.1136/bmj.c1571
69. Other ElSohly, Mahmoud A. Marijuana and the Cannabinoids. 2007
70. Other Stafford, Peter G.; Bigwood, Jeremy. Psychedelics Encyclopedia. 1992
71. Other Barber EJ. Prehistoric Textiles: The Development of Cloth in the Neolithic and Bronze Ages with Special Reference to the Aegean. 1992
72. Other Anthony, David W. The Horse, the Wheel, and Language: How Bronze-Age Riders from the Eurasian Steppes Shaped the Modern World. 2007
73. Other Ellens, J. Harold. Seeking the Sacred with Psychoactive Substances: Chemical Paths to Spirituality and to God. 2014
74. Other Rudgley, Richard. The Encyclopedia of Psychoactive Substances. 1998
75. Other Franck, Mel. Marijuana Grower's Guide. 1997
76. Other Rubin, Vera D. Cannabis and Culture. 1976
77. Other Cunliffe, Barry W. The Oxford Illustrated History of Prehistoric Europe. 2001
78. Other Schultes, Richard Evans. Hallucinogenic Plants. 1976
79. Other Staelens, Stefanie. The Bhang Lassi Is How Hindus Drink Themselves High for Shiva. 10 March 2015
80. Other Vij. Textbook Of Forensic Medicine And Toxicology: Principles And Practice. 2012
81. Other ShorterOxfordEnglishDictionary
82. Other Spanish Word Histories and Mysteries: English Words That Come From Spanish. 2007
83. Journal / agency Ren M, Tang Z, Wu X, Spengler R, Jiang H, Yang Y, Boivin N. The origins of cannabis smoking: Chemical residue evidence from the first millennium BCE in the Pamirs. Science Advances. June 2019. doi:10.1126/sciadv.aaw1391 · PMID 31206023 · PMC6561734
84. Other Donahue, Michelle. Earliest evidence for cannabis smoking discovered in ancient tombs. 12 June 2019
85. Other Walton, Robert P. Marijuana, America's New Drug Problem. 1938
86. Other Taymiyya, Ibn. Le haschich et l'extase. 2001
87. Other Rubin, Vera. Cannabis and Culture. 1975
88. Other Booth, Martin. Cannabis: A History. 2004
89. Other David E. Newton. Marijuana: A Reference Handbook, 2nd Edition. 2017
90. Other Eileen Konieczny, Lauren Wilson. Healing with CBD. 2018
91. Other Pilkington, Mark. Clouds of smoke. 2005-07-27
92. Other Iversen, Leslie L. The Science of Marijuana. 2007
93. Other A Collection of the Laws of Mauritius and Its Dependencies. 1867
94. Other Bunyapraphatsōn, Nanthawan. Medicinal and poisonous plants. 1999
95. Other Statement of Dr. William C. Woodward
96. Other https://archive.org/stream/actsofparl1923v01cana#page/134/mode/2up. 1923
97. Other Health products containing cannabis or for use with cannabis: Guidance for the Cannabis Act, the Food and Drugs Act, and related regulations. 11 July 2018
98. Other Willoughby WW. Opium as an international problem. 1925
99. Other Google books GJm-XDLJe1QC Opium as an international problem: the Geneva conferences – Westel Woodbury Willoughby
100. Other USStatute 75 238 50 551 1937 8 2
101. Other Booth, Martin. Cannabis: A History. 2004
102. Other Michael Tonry. Crime and Justice. 2015
103. Harm reduction site Use drop-down menu on site to view Netherlands entry.)
104. Other Drugs Policy in the Netherlands
105. Other Amsterdam Will Ban Tourists from Pot Coffee Shops. 27 May 2011
106. Other Dockterman, Eliana. Marijuana Now the Most Popular Drug in the World. 29 June 2012
107. Other World Drug Report 2017
108. Journal / agency Habibi, Roojin; Hoffman, Steven J. Legalizing Cannabis Violates the UN Drug Control Treaties, But Progressive Countries Like Canada Have Options. Ottawa Law Review. March 2018
109. Other Bewley-Taylor, David; Jelsma, Martin; Rolles, Steve; Walsh, John. Cannabis regulation and the UN drug treaties. June 2016
110. Other Angell, T. World Health Organization Recommends Reclassifying Marijuana Under International Treaties. 2019
111. Other Levinson, David. Encyclopedia of Crime and Punishment. 2002
112. Other Many Dutch coffee shops close as liberal policies change, Exaptica. 27 November 2007
113. Other 43 Amsterdam coffee shops to close door", Radio Netherlands, Friday 21 November 2008. link 2
114. Other O'Sullivan, Feargus. Why the Mayor of Copenhagen Wants to Get Into the Marijuana Business. 3 March 2014
115. Other Johnston, Ian. As cannabis is widely legalised, China cashes in on an unprecedented boom. 5 January 2014
116. Other Liljas, Per. Could Thailand, which gave world the bong, legalise cannabis for medicinal use? After failed war on drugs, attitudes have softened. 3 June 2017
117. Other Marijuana goes legal in Washington state amid mixed messages. 7 December 2012
118. Other Duke, Alan. 2 states legalize pot, but don't 'break out the Cheetos' yet. 8 November 2012
119. Other Marijuana clubs ring in new year in Colorado as legalized pot smoking begins. 1 January 2013
120. Other Mintz, Horward. Medical pot: California Supreme Court allows cities to ban weed dispensaries. 6 May 2013
121. Other US drug control agency will move to reclassify marijuana in a historic shift, AP sources say. 2024-04-30
122. Other Biden administration plans to drastically change federal rules on marijuana
123. Other Trump expands access to cannabis in a major shift in drug policy. 2025-12-18
124. Other Baker, Vicky. Marijuana laws around the world: what you need to know. 11 December 2013
125. Other Castaldi, Malena. Uruguay pharmacies start selling cannabis straight to consumers. 19 July 2017
126. Other Scotti, Monique. Marijuana to be legal in Canada starting October 17, Trudeau confirms. 20 June 2018
127. Other Sapra, Bani. Canada becomes second nation in the world to legalize marijuana. 20 June 2018
128. Other Uttarakhand To Become First Indian State To Legalise Cannabis Cultivation. 27 November 2015
129. Harm reduction site South Asia Regional Profile Report
130. Other Alchimia Blog, Medical marijuana news, December 2015. link 2
131. Other Butler, Patrick. Cannabis is legal in Canada – here's what you need to know. 17 October 2018
132. Other Cannabis Act (S.C. 2018, c. 16)
133. Other This Application Seems Rigorous. Are All These Hoops Necessary?. 5 July 2018
134. Other Will Craft Cannabis Growers in Canada Succeed Like Craft Brewers?. October 2018
135. Other Parliament of the Czech Republic. Explanatory Report to Act No. 112/1998 Coll., which amends the Act No. 140/1961 Coll., the Criminal Code, and the Act No. 200/1990 Coll., on misdemeanors. 1998
136. Other Castaneda, Jorge G. The summit of muted intentions. 31 March 2012
137. Other Congreso aprobó, en último debate, uso medicinal de la marihuana. 25 May 2016
138. Other Dosis máximas de droga para consumo ya están vigentes
139. Other Ecuador: Aprueban tenencia de drogas para consumo" at El Nuevo Herald. link 2
140. Other Ecuador could regulate the drug industry
141. Harm reduction site Drug policy profiles – Portugal. 1 June 2011
142. Other Lindeque, Mia. Dagga users celebrate following ConCourt ruling on private use
143. Other Williams, Sean. Mexico Aims to Legalize Recreational Marijuana Before October. 28 April 2019
144. Other Vélez, Manuel. Ley de Narcomenudeo. 17 October 2009
145. Other Mexico marijuana: Top court decriminalises recreational use of cannabis. 2021-06-28
146. Other Germany becomes largest EU country to legalize cannabis for recreational use. 2024-04-01
147. Other Ross, Selena. All eyes on Canada as first G7 nation prepares to make marijuana legal. 6 June 2018
148. Other Marijuana Overview
149. Other Smith, Tasha. "New Amsterdam" No More? Spain's Cannabis Clubs Fight to Stay Open. 5 June 2018
150. Other Haines, Gavin. Everything you need to know about marijuana smoking in the Netherlands. 21 February 2017
151. Other The Legal Situation of Cannabis in the Netherlands. 20 May 2020
152. Other Bubola, Emma. Malta Becomes First E.U. Country to Legalize Marijuana. 15 December 2021
153. Other Massa, Silja. Kevytkannabis saapui Viroon – Suomalaisturistin ei kannata ostaa tuliaisiksi Virossa laillisia tuotteita. 29 June 2019
154. Other Lebanon legalizes cannabis farming for medicinal use. 21 April 2020
155. Other Is Weed Legal in Japan? And Other Vacation Info for Cannabis Users. 6 February 2020
156. Other Here are the absolute worst places on earth to be caught with weed
157. Other Bong arm of the law: South Korea says it will arrest citizens who smoke weed in Canada. 23 October 2018
158. Journal / agency Bow, Eric. The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspectives in Medicinal Chemistry. 2016. doi:10.4137/PMC.S32171 · PMID 27398024 · PMC4927043
159. Journal / agency Thomas, A. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007. doi:10.1038/sj.bjp.0707133 · PMID 17245363 · PMC2189767
160. Journal / agency Wilson RI, Nicoll RA. Endocannabinoid signaling in the brain. Science. April 2002. doi:10.1126/science.1063545 · PMID 11976437
161. Journal / agency Oleson EB, Cheer JF. A brain on cannabinoids: the role of dopamine release in reward seeking. Cold Spring Harbor Perspectives in Medicine. August 2012. doi:10.1101/cshperspect.a012229 · PMID 22908200 · PMC3405830
162. Journal / agency Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E. Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. February 2006. doi:10.1007/s00210-006-0033-x · PMID 16489449
163. Journal / agency Hejazi N, Zhou C, Oz M, Sun H, Ye JH, Zhang L. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Molecular Pharmacology. March 2006. doi:10.1124/mol.105.019174 · PMID 16332990
164. Journal / agency Xiong W, Cheng K, Cui T, Godlewski G, Rice KC, Xu Y, Zhang L. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology. May 2011. doi:10.1038/nchembio.552 · PMID 21460829 · PMC3388539
165. Other Hall, Wayne; Pacula, Rosalie Liccardo. Cannabis Use and Dependence: Public Health and Public Policy. 2003
166. Journal / agency Hollister, Leo E. Health aspects of cannabis. Pharma Review. March 1986. doi:10.1016/S0031-6997(25)06862-0 · PMID 3520605
167. Other Barceloux, Donald G. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. 2012
168. Other Baselt, Randall Clint. Disposition of Toxic Drugs and Chemicals in Man. 2008
169. Other Shaw, Leslie M.; Kwong, Tai C. The Clinical Toxicology Laboratory: Contemporary Practice of Poisoning Evaluation. 2001
170. Other Kelly, John; Addanki, Krishna; Bagasra, Omar. The Non-Specificity of the Duquenois-Levine Field Test for Marijuana. January 2012
171. Journal / agency Venkatratnam A, Lents NH. Zinc reduces the detection of cocaine, methamphetamine, and THC by ELISA urine testing. Journal of Analytical Toxicology. July 2011. doi:10.1093/anatox/35.6.333 · PMID 21740689
172. Journal / agency Lin CN, Strathmann FG. Elevated urine zinc concentration reduces the detection of methamphetamine, cocaine, THC and opiates in urine by EMIT. Journal of Analytical Toxicology. 10 July 2013. doi:10.1093/jat/bkt056 · PMID 23843421

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