Psilocybin mushrooms
Also called Psilocybin, Magic Mushrooms, Shrooms, 4-PO-DMT
Dosage
When sources disagree, both rows are shown as published. Nothing is averaged or merged.
Oral
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | 2.5 mg Psilocybin PW | 2.5–10 mg Psilocybin PW | 10–25 mg Psilocybin PW | 25–50 mg Psilocybin PW | 50 mg Psilocybin+ PW |
| TripSit | – | 0.5–1.5 g TS | 1.5–3.5 g TS | 3.5 g+ TS | – |
NOTE: Dosage ranges will vary between fungus strains. The doses given are for *dried* mushrooms, which are many times more potent by weight than those consumed when wet. Onset varies depending on dosage, common doses are normally felt within one hour. TS
TripSit dose text
TripSit's factsheet also states its doses as text.
Oral Light: 0.5-1.5g Common: 1.5-3.5g Strong: 3.5g+ | NOTE: Dosage ranges will vary between fungus strains. The doses given are for *dried* mushrooms, which are many times more potent by weight than those consumed when wet. TS
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Duration
Oral, drawn at the midpoint of each PsychonautWiki range.
| Route · source | Onset | Come-up | Peak | Offset | Total | After-effects |
|---|---|---|---|---|---|---|
| Oral · PsychonautWiki | 20–45 minutes PW | 1–1.5 hours PW | 2–2.5 hours[8] PW | 2.5–3.5 hours PW | 6–8 hours PW | 4–24 hours PW |
TripSit factsheet
Mixing
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
Other documented combinations
- Unsafe Tramadol - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures. PW
- Unsafe Lithium - Lithium is commonly prescribed in the treatment of bipolar disorder; however, studies find it can significantly increase the risk of and seizures when combined to psychedelics. As a result, this combination should be strictly avoided. PW
- Uncertain Amphetamines - Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences PW
- Uncertain Cannabis: Cannabis can have an unexpectedly strong and unpredictable synergy with psilocybin mushrooms. While it is commonly used to intensify or prolong the mushrooms' effects, caution is highly advised as mixing these substances can significantly increase the risk of anxiety, paranoia, panic attacks, and psychosis. Anecdotal reports often describe the ingestion of cannabis as the triggering event for a bad trip or psychosis. Users are advised to start off with only a fraction (e.g. 1/4th - 1/3rd) of their typical cannabis dose and space out hits to avoid accidental over-intake.[9] PW
- Uncertain Cocaine - Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences PW
TripSit combination chart
TripSit rates each pairing. Only pairings with a number carry a citation from TripSit. See the whole chart, with TripSit's note for every pairing.
Low Risk & Synergy
Risks and toxicity
Numerous studies have found that psilocybin mushrooms are physiologically well-tolerated and has an extremely low toxicity relative to dose. There is no evidence for long-lasting effects on the brain or other organs and there are no documented deaths attributed to the direct effects of psilocybin mushrooms toxicity.[15] PW
However, it is worth noting that while they may not be capable of causing direct bodily toxicity or death, their use can still present serious hazards. PW
For example, they are capable of strongly impairing the user's judgment and attention span, which may promote erratic or dangerous behaviors. In extreme cases, the user may experience powerful delusions e.g. that they are actually inside of a dream and therefore physically invincible, or that they are being "chased by demons". This may prompt them to jump off of a building or run into oncoming traffic.[15] PW
Additionally, intense negative experiences and psychotic episodes (i.e. "bad trips") can cause lasting psychological trauma if not properly managed or treated afterward. This is particularly a concern in non-supervised settings or when heavy doses are used. PW
Finally, it should be noted that evidence of psilocybin mushrooms' effectiveness as a mental health treatment only applies to the controlled procedures used in clinical settings. They are not considered the entire treatment because the current evidence suggests they must be combined with professional psychotherapy to produce lasting effects. PW
Without the appropriate safeguards, attempts at self-medicating with psilocybin mushrooms may actually worsen mental health issues. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
It is strongly advised to use harm reduction practices if using this substance. These include: PW
- Taking the substance under the supervision of a tripsitter for one's first time or while experimenting with a higher dose PW
- Starting off with a dose in the low-common range and monitoring for unusual reactions (e.g. mania, delusions) or sensitivity PW
- Not exceeding the listed heavy dose. If heavy doses are required, a tolerance break is advised instead. Heavy doses greatly increase the risk of negative effects PW
- Keeping a supply of benzodiazepines or antipsychotics (e.g. Seroquel) to abort the trip in the case of overwhelming anxiety or psychosis PW
Lethal dosage
The toxicity of psilocybin and psilocin is extremely low. In rats, the median lethal dose (LD₅₀) of psilocybin when administered orally is 280 milligrams per kilogram (mg/kg). PW
Psilocybin comprises approximately 1% of the weight of Psilocybe cubensis and so nearly 1.7 kilograms (3.7 lb) of dried mushrooms or 17 kilograms (37 lb) of fresh mushrooms would be required for a 60 kilogram (130 lb) person to reach the 280 mg/kg LD50 value of rats. PW
Based on the results of animal studies, the lethal dose of psilocybin has been extrapolated to be 6 grams, 1000 times greater than the effective dose of 6 milligrams. Unlike many highly prohibited substances, it is effectively impossible to physically overdose on. PW
Psychosis and mental disorder risk
Psilocybin mushrooms can exacerbate symptoms (e.g. delusions, mania, psychosis) of various mental disorders. Additionally, they can precipitate the early onset of schizophrenia in vulnerable individuals.[15] PW
Those with a personal or family history of mental disorders, particularly psychotic disorders like schizophrenia, should not use psilocybin mushrooms without consulting a qualified medical professional. PW
Dependence and abuse potential
Like other serotonergic psychedelics, psilocybin mushrooms have low abuse and no physical dependence potential.[16] PW
There are no literature reports of successful attempts to train animals to self-administer a serotonergic psychedelic, which is predictive of abuse liability, indicating that it does not have the necessary pharmacology to either initiate or maintain dependence.[16] PW
Additionally, there is no human clinical evidence that psilocybin mushrooms causes addiction. Finally, there is virtually no withdrawal syndrome when chronic use of psilocybin mushrooms is stopped. PW
Tolerance to the effects of psilocybin builds almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). PW
Psilocybin exhibits cross-tolerance with all psychedelics, meaning that after the consumption of psilocybin all psychedelics will have a reduced effect. PW
Hallucinogen-perception persisting disorder (HPPD)
In rare cases, psilocybin mushrooms may trigger hallucinogen persisting perception disorder (HPPD) in some individuals. The cause is unclear; however, explanations in terms of psilocybin physically remaining in the body for months or years after consumption have been discounted by experimental evidence.[17] PW
Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action on brain chemistry, and varies according to the susceptibility of the individual to the disorder.[18] PW
Testing
Effects
visual distortioncolor enhancementsense of connectedness with naturesense of well beingsense of wonder TS
Overview
Psilocybin mushrooms (also known as magic mushrooms, psychedelic mushrooms, and shrooms) are a family of psychoactive fungi that contain psilocybin, a psychedelic substance of the tryptamine class. The mechanism of action is not fully known, although binding activity at serotonin receptors is thought to be involved. PW
Fungi containing psilocybin, a prototypical psychedelic with similar effects to LSD, but with a shorter duration; also considered as being more confusing, introspective and entheogenic. Usually refers to psilocybe mushrooms rather than Amanitas, which have different effects. Are considered physically safe if properly identified, which should always be done by an expert.[1] TS
Psilocybin mushroom is a type of hallucinogenic mushroom and a polyphyletic informal group of fungi that contain the prodrug psilocybin, which is metabolised into the psychedelic compound psilocin following ingestion. Rather than referring to one single mushroom species, the term "psilocybin mushroom" refers to a broad group of fungi found across several genera. Other compounds such as baeocystin, norbaeocystin, aeruginascin, and β-carbolines may modulate effects. The most potent species are members of genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from approximately a dozen other genera, including Panaeolus (including Copelandia), Inocybe, Pluteus, Gymnopilus, and Pholiotina.[2]
Amongst other cultural applications, psilocybin mushrooms are used as recreational drugs. While psilocybin mushrooms were used ritualistically in pre-Columbian Mexico for religious and divinatory purposes, their historical use elsewhere was rare and is often exaggerated. Such practices were suppressed after European colonization.[3]
Modern Western interest began in the mid-20th century with figures like R. Gordon Wasson and Timothy Leary popularizing their study and use. Legal status varies widely, with some U.S. states decriminalizing or allowing therapeutic use, and international treaties generally regulate only the active compounds, not the mushrooms themselves. Research has increasingly focused on therapeutic potential for depression, anxiety, and substance use disorders. Recent scientific literature has also expanded interest in the taxonomy, ecology, and neurobiology of psilocybin-containing fungi, not only their psychoactive properties.[6]
History
Early
The use of psilocybin mushrooms by humans in religious ceremonies dating back thousands of years is contested. Despite popular narratives portraying psychedelics as ancient, widespread, and primarily used by shamans for therapeutic healing, careful anthropological and historical research shows their traditional use was limited, recent, and culturally specific, with modern Western interpretations largely shaped by idealization, tourism, and ideological agendas. Reliable evidence shows that psilocybin mushrooms were used ritualistically in pre-Columbian Mexico but were otherwise rare, with most claims of ancient widespread use being exaggerated or misinterpreted.[5] WP
The Tassili Mushroom Figure was discovered in Tassili, Algeria has been argued to provide evidence of an early psilocybin-containing mushroom cult. 6,000-year-old pictographs discovered near the Spanish town of Villar del Humo illustrate several mushrooms that have been argued to be Psilocybe hispanica, a hallucinogenic species native to the area. Some scholars have also interpreted archaeological artifacts from Mexico and the so-called Mayan "mushroom stones" of Guatemala as evidence of ritual and ceremonial use of psychoactive mushrooms in the Mayan and Aztec cultures of Mesoamerica.[19]
The hallucinogenic species of the Psilocybe genus have a history of use among the native peoples of Mesoamerica for religious communion, divination, and healing, from pre-Columbian times to the present day. Aztecs and Mazatecs referred to psilocybin mushrooms as genius mushrooms, divinatory mushrooms, and wondrous mushrooms when translated into English. Bernardino de Sahagún reported the ritualistic use of teonanácatl by the Aztecs when he traveled to Central America after the expedition of Hernán Cortés.[21–24] WP
After the Spanish conquest, Catholic missionaries campaigned against the cultural tradition of the Aztecs, dismissing the Aztecs as idolaters, and the use of hallucinogenic plants and mushrooms, together with other pre-Christian traditions, was quickly suppressed. The Spanish believed the mushroom allowed the Aztecs and others to communicate with demons. Despite this history, the use of teonanácatl has persisted in some remote areas.[25]
A 2024 research paper identified Psilocybe maluti as a new described species from the Free State Province of South Africa and Lesotho in Southern Africa. Anecdotal reports suggests the mushroom was used spiritually and traditionally by Basotho healers, marking it the only documented instance of traditional hallucinogenic mushroom use in Africa and the earliest recorded reference to such practices in Sub-Saharan Africa.[27] WP
Modern
The first mention of hallucinogenic mushrooms in European medicinal literature was in the London Medical and Physical Journal in 1799. A man served Psilocybe semilanceata mushrooms he had picked for breakfast in London's Green Park to his family. The apothecary who treated them later described how the youngest child "was attacked with fits of immoderate laughter, nor could the threats of his father or mother refrain him."[28]
In 1955, Valentina Pavlovna Wasson and R. Gordon Wasson became the first known European Americans to actively participate in an indigenous mushroom ceremony. The Wassons did much to publicize their experience, even publishing an article on their experiences in Life on May 13, 1957. In 1956, Roger Heim identified the psychoactive mushroom the Wassons brought back from Mexico as Psilocybe, and in 1958, Albert Hofmann first identified psilocybin and psilocin as the active compounds in these mushrooms. The isolation of psilocybin was the culmination of a broader research effort that involved Indigenous collaborators, anthropologists, mycologists, universities, pharmaceutical laboratories, and intelligence-linked funding during the Cold War.[30–34] WP
Inspired by the Wassons' Life article, Timothy Leary traveled to Mexico to experience psilocybin mushrooms himself. When he returned to Harvard in 1960, he and Richard Alpert started the Harvard Psilocybin Project, promoting psychological and religious studies of psilocybin and other psychedelic drugs. Alpert and Leary sought to conduct research with psilocybin on prisoners in the 1960s, testing its effects on recidivism. This experiment reviewed the subjects six months later, and found that the recidivism rate had decreased beyond their expectation, below 40%. This, and another experiment administering psilocybin to graduate divinity students, showed controversy. Shortly after Leary and Alpert were dismissed from their jobs by Harvard in 1963, they turned their attention toward promoting the psychedelic experience to the nascent hippie counterculture.[35]
The popularization of entheogens by the Wassons, Leary, Terence McKenna, Robert Anton Wilson, and many others led to an explosion in the use of psilocybin mushrooms throughout the world. By the early 1970s, many psilocybin mushroom species were described from temperate North America, Europe, and Asia and were widely collected. Books describing methods of cultivating large quantities of Psilocybe cubensis were also published, for instance Psilocybin: Magic Mushroom Grower's Guide (1976) by Terence McKenna and Dennis McKenna. The availability of psilocybin mushrooms from wild and cultivated sources has made them one of the most widely used psychedelic drugs. WP
At present, psilocybin mushroom use has been reported among some groups spanning from central Mexico to Oaxaca, including groups of Nahua, Mixtecs, Mixe, Mazatecs, Zapotecs, and others. Psilocybin retreats such as MycoMeditations also exist in countries like Jamaica, where psilocybin mushrooms are legal. An important figure of mushroom usage in Mexico was María Sabina, who used native mushrooms, such as Psilocybe mexicana in her practice.[26]
Modern scientific and cultural interest in psilocybin mushrooms has continued to grow, especially because of renewed psychiatric and neuroscientific research in the 21st century.[38] WP
Legal status
- Internationally, psilocybin (but not psilocybin mushrooms) is a Schedule I drug under the Convention on Psychotropic Substances. "The cultivation of plants from which psychotropic substances are obtained is not controlled by the Vienna Convention.... Neither the crown (fruit, mescal button) of the Peyote cactus nor the roots of the plant Mimosa hostilis nor Psilocybe mushrooms themselves are included in Schedule 1, but only their respective principals, mescaline, DMT, and psilocin." PW
- Austria: Psilocybin containing mushrooms are illegal to possess in dried form, to sell and to offer, give or get somebody under the SMG (Suchtmittelgesetz Österreich). It is illegal to grow them with the intention of "producing psychotropic substances" (as psilocin and psilocybin) mentioned in BGBl. III Nr. 148/1997.[39] PW
- Bahamas: Psilocybin mushrooms are legal to possess, grow, and consume. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Belgium: Possession and sale of mushrooms have been illegal since 1988. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Brazil: Psilocybin Mushrooms derived psychoactive substances targeted for unjustified consumption are illegal to possess, store, transport, import, export, prescribe, administer, sell and advertise, regardless of no intent of profit and in any form. Cultivation of the former, however, only under the premise of "botanical purposes", or similar, is perfectly allowed due to legal gap in which Psilocybe mushrooms themselves are not explicitly listed as sources of potential psychotropic substances. Use of Psilocybin containing mushrooms within religious cults are constitucionally and internationally protected from antidrug policies and are, likewise, allowed.[40] PW
- British Virgin Isles: The sale of mushrooms is illegal, but possession and consumption is legal. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Bulgaria: The sale of mushrooms is illegal, but possession and consumption is legal. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Canada: Psilocybin and psilocin are illegal to possess, obtain or produce without a prescription or license as they are Schedule III under the Controlled Drugs and Substances Act; however, dried psilocybin mushrooms are openly sold on dozens of Canadian websites. Spores and growing kits are legal to possess.[41] PW
- Cyprus: Psilocybin mushrooms are illegal to possess, grow, sale, and consume. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Czech Republic: The distribution (including sale) of mushrooms is illegal, but consumption is legal. The possession of over 40 hallucinogenic caps is considered a crime if they contain more than 50mg of psilocin or the corresponding amount of psilocybin. The possession of more than 40g of hallucinogenic mycelium is considered a crime. If these limits are not exceeded, the act is considered a minor offense and a fine of up to 15 thousand CZK may be imposed. PW
- Denmark: Psilocybin mushrooms are illegal to possess, grow, sale, and consume. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Finland: Psilocybin mushrooms are illegal to possess, grow, sale, and consume. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Germany: Psilocybin is illegal to produce, possess or sale under Schedule I of the Narcotics Act (Anlage I BtMG). Consumption is not illegal. The mushroom and spores by itself are not illegal and only become illegal when containing Psilocybin or Psilocin.[42] PW
- Greece: Psilocybin mushrooms are illegal to possess, grow, sale, and consume. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Iceland: The sale of Psilocybin mushrooms is illegal, but possession and consumption is legal. PW
- India: Psilocybin mushrooms are illegal to possess, grow, sale, and consume. However, it is reported that many police departments in undeveloped areas are unaware of the prohibition. PW
- Ireland: Psilocybin mushrooms are illegal to possess, grow, sale, and consume. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Italy: Psilocybin is a schedule I drug (Tabella 1).[43] PW
- Japan: Psilocybin mushrooms are illegal to possess, grow, sale, and consume. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Latvia: Hallucinogenic mushrooms, psilocin and psilocybin are Schedule I controlled substances.[44] PW
- Luxembourg: Psilocybin is a prohibited substance[45] PW
- Mexico: The possession, growth, sale and consumption of mushrooms is illegal. Rules are relaxed regarding religious use however. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- The Netherlands: The possession, growth, sale and consumption of mushrooms is illegal. However, due to a legal loophole, psilocybin truffles can be legally possessed, grown, sold and consumed. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- New Zealand: Psilocybin is a Class A substance. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Norway: Possession, growth, sale and consumption of mushrooms is illegal. Spores, even though not containing psilocybin, are also illegal. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- Sweden: Sveriges riksdag added psilocybin mushrooms to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of Aug 1, 1999, published by Medical Products Agency.[46] PW
- Switzerland: Mushrooms of the species Conocybe, Panaeolus, Psilocybe and Stropharia are controlled under Verzechnis D.[47] PW
- Turkey: The possession, growth, sale and consumption of mushrooms is illegal. PW⚠ PsychonautWiki itself has flagged this text: citation needed.
- United Kingdom: According to the 2005 Drugs Act, fresh and prepared psilocybin mushrooms are Class A.[48] PW
- United States: Psilocybin and psilocin are Schedule I drugs under the Controlled Substances Act of 1970. This means it is illegal to manufacture, buy, possess, process, or distribute without a license from the Drug Enforcement Administration (DEA). Several US states and cities have decriminalised Psilocybin mushrooms.[49] PW
- Oregon: Oregon Measure 109 legalized the use of Psilocybin mushrooms to licensed service providers administering to individuals 21 years of age or older. PW
- Colorado: Colorado proposition 122 legalizes psychedelic plants and fungi for adults age 21 and older. PW
Legal status
The legality of the cultivation, possession, and sale of psilocybin mushrooms and psilocybin and psilocin varies from country to country. WP
After Oregon Measure 109, in 2020, Oregon became the first US state to decriminalize psilocybin and legalize it for therapeutic use. However, selling psilocybin without being licensed may still attract fines or imprisonment. In 2022 Colorado legalized consumption, growing, and sharing for personal use, though sales are prohibited while regulations are being drafted. Other jurisdictions in the United States have decriminalized psilocybin mushrooms.[50–53] WP
Furthermore, buying spores of mushroom species containing psilocybin online in the United States is legal in all states except Georgia, Idaho and California. This is because only fruiting mushrooms and mycelium contain psilocybin, a federally banned substance. A technical caveat to consider, however, is that the distributed spores must not be intended to be used for cultivation, but allowed for microscopy purposes.[54]
United nations
Internationally, mescaline, dimethyltryptamine (DMT), and psilocin, are Schedule I drugs under the Convention on Psychotropic Substances. The Commentary on the Convention on Psychotropic Substances notes, however, that the plants containing them are not subject to international control:[57] WP
The cultivation of plants from which psychotropic substances are obtained is not controlled by the Vienna Convention... Neither the crown (fruit, mescal button) of the Peyote cactus nor the roots of the plant Mimosa hostilis nor Psilocybe mushrooms themselves are included in Schedule 1, but only their respective principals, mescaline, DMT, and psilocin. WP
Pharmacology
Chemistry
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References
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- Other Oregon Measure 109, Psilocybin Mushroom Services Program Initiative (2020). Nov 3, 2020
- Other Brown, Jennifer. Colorado becomes second state to legalize "magic mushrooms". 10 November 2022
- Other Kenny, Andrew. A gray market emerges in Colorado after voters approved psychedelic substances. July 4, 2023
- Other Colorado Proposition 122, Decriminalization and Regulated Access Program for Certain Psychedelic Plants and Fungi Initiative (2022). Nov 8, 2022
- Other Frequently Asked Questions. Jul 2, 2022
- Other Psilocybin Drug Fact Sheet. April 21, 2020
- Other COURT OF APPEALS OF WISCONSIN PUBLISHED OPINION. June 21, 2007
- Other DMT – UN report. 2001-03-31
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